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C-Type NatriureticPeptide (1-53), human TFA is the 1-53 fragment of C-Type NatriureticPeptide. C-Type NatriureticPeptide TFA is natriureticpeptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone .
Atrial NatriureticPeptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriureticpeptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial NatriureticPeptide has the potential for cardiovascular diseases research .
C-Type NatriureticPeptide (1-53), human is the 1-53 fragment of C-Type NatriureticPeptide. C-Type NatriureticPeptide is natriureticpeptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone .
Atrial natriureticpeptide (3-28) (human) (ANP (3-28) (human)) is a peptide hormone that is synthesized and secreted by the atrial myocardium. Atrial natriureticpeptide (3-28) (human) is involved in the regulation of blood pressure, fluid balance, and electrolyte homeostasis .
Carperitide (Atrial NatriureticPeptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial NatriureticPeptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.
Atrial NatriureticPeptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
Atrial NatriureticPeptide (ANP) (1-28), rat (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
Brain NatriureticPeptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) .
Brain NatriureticPeptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) .
Carperitide acetate (Atrial NatriureticPeptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.
Vasonatrin Peptide (VNP) is a chimera of atrial natriureticpeptide (ANP) and C-type natriureticpeptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriureticpeptide (ANP) and C-type natriureticpeptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriureticpeptide (NP) composed of C-type natriureticpeptide (CNP) fused to the C-terminus of Dendroaspis natriureticpeptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .
Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriureticpeptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .
SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriureticpeptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity .
ANP (1-30), frog is a peptide fragment of atrial natriureticpeptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriureticpeptide) analogue, binds to NPR-B(natriureticpeptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research .
NPR-C activator 1 (Compound 1) is a potent activator of natriureticpeptide receptor C (NPR-C). C-type natriureticpeptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties .
Vosoritide (BMN 111) acetate is a natriureticpeptide receptor 2 (NPR2) agonist that acts on the proliferation and differentiation of chondrocytes to promote bone growth .
A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriureticpeptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells .
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriureticpeptide receptor response .
Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriureticpeptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation .
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriureticpeptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .
Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 .
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .
C-Type NatriureticPeptide (1-53), human TFA is the 1-53 fragment of C-Type NatriureticPeptide. C-Type NatriureticPeptide TFA is natriureticpeptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone .
C-Type NatriureticPeptide (1-53), human is the 1-53 fragment of C-Type NatriureticPeptide. C-Type NatriureticPeptide is natriureticpeptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone .
Brain NatriureticPeptide-45, rat (BNP-45, rat) is a circulating form of rat brain natriureticpeptide isolated from rat heart with potent hypotensive and natriuretic potency .
Brain NatriureticPeptide-45, mouse (BNP-45, mouse) is a circulating form of mouse brain natriureticpeptide isolated from mouse heart with potent hypotensive and natriuretic potency .
Nesiritide (Brain NatriureticPeptide-32 human) is an agonist of natriureticpeptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.
Atrial NatriureticPeptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriureticpeptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial NatriureticPeptide has the potential for cardiovascular diseases research .
Brain NatriureticPeptide-45, rat TFA (BNP-45, rat TFA) is a circulating form of rat brain natriureticpeptide isolated from rat heart with potent hypotensive and natriuretic potency .
C-Type NatriureticPeptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriureticpeptide receptor B (NPR-B) agonist. C-Type NatriureticPeptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .
C-Type NatriureticPeptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriureticpeptide receptor B (NPR-B) agonist. C-Type NatriureticPeptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .
Atrial natriureticpeptide (3-28) (human) (ANP (3-28) (human)) is a peptide hormone that is synthesized and secreted by the atrial myocardium. Atrial natriureticpeptide (3-28) (human) is involved in the regulation of blood pressure, fluid balance, and electrolyte homeostasis .
BNP (1-21), Pro (Human) is a peptide containg 21 amino acids. B-Type NatriureticPeptide (BNP), a cardiac natriuretic hormone. BNP together with the highly homologous atrial natriureticpeptide, it forms a dual natriureticpeptide system of the heart. BNP is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life .
Carperitide (Atrial NatriureticPeptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial NatriureticPeptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.
Atrial NatriureticPeptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
Atrial NatriureticPeptide (ANP) (1-28), rat (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
Brain NatriureticPeptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) .
Brain NatriureticPeptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) .
Carperitide acetate (Atrial NatriureticPeptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.
L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriureticpeptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity .
Vasonatrin Peptide (VNP) is a chimera of atrial natriureticpeptide (ANP) and C-type natriureticpeptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriureticpeptide (ANP) and C-type natriureticpeptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriureticpeptide (NP) composed of C-type natriureticpeptide (CNP) fused to the C-terminus of Dendroaspis natriureticpeptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .
AP 811 is a selective atrial natriureticpeptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation .
AP 811 acetate is a selective atrial natriureticpeptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 acetate displays >20000-fold selectivity for NPR3 over NPR1. AP 811 acetate abolishes ANP-induced pump stimulation .
Ularitide (Urodilatin), natriureticpeptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure .
ANP (1-30), frog is a peptide fragment of atrial natriureticpeptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.
Atriopeptin II rat, mouse is an atrial natriureticpeptide, which acts as diuretic and natriuretic agent, and a potent relaxant of vascular smooth muscle .
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriureticpeptide) analogue, binds to NPR-B(natriureticpeptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research .
Vosoritide (BMN 111) acetate is a natriureticpeptide receptor 2 (NPR2) agonist that acts on the proliferation and differentiation of chondrocytes to promote bone growth .
Atrial Natriuretic Factor (5-27) (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriureticpeptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells .
Urodilatin is an analogue of ANF-(99-126). Urodilatin is a diuretic-natriuretic regulatory peptide. Urodilatin can be used for research of acute renal failure, congestive heart failure, and bronchial asthma, etc .
Uroguanylin-15 (Rat) is a biological active peptide. (Uroguanylin is a natriureticpeptide, a hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. Uroguanylin and guanylin are related peptides that activate common guanylate cyclase signaling molecules in the intestine and kidney. Uroguanylin was isolated from urine and duodenum but was not detected in extracts from the colon of rats.)
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriureticpeptide receptor response .
PL-3994 is a natriureticpeptide receptor-A (NPR-A) agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. PL-3994 produces concentration-dependent relaxation of pre-contracted guinea-pig trachea with an IC50 value of 42.7 nM .
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .
A 71915 is a highly potent and competitive natriureticpeptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [ 125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells .
Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure .
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .
Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriureticpeptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation .
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriureticpeptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .
Natriuretic peptide A/NPPA is critical for cardiorenal homeostasis and regulates vascular remodeling and energy metabolism by binding to NPR1. This stimulates the production of c, activating PRKG1 to respond differently. Natriuretic peptides A/NPPA Protein, Human (P. pastoris, His) is the recombinant human-derived Natriuretic peptides A/NPPA protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Natriuretic peptides A/NPPA Protein, Human (P. pastoris, His) is 38 a.a., with molecular weight of 5.9 kDa.
NPPB Protein, a member of the natriuretic peptide family, functions as a key regulator of cardiovascular homeostasis. As a hormone, NPPB is primarily produced and released by cardiac ventricular myocytes in response to increased pressure and volume. Upon secretion, it acts on target tissues, including the heart and blood vessels, to induce vasodilation, natriuresis, and diuresis, collectively contributing to the maintenance of blood pressure and fluid balance. NPPB's pleiotropic effects underscore its crucial role in cardiovascular physiology and its potential therapeutic implications in managing cardiovascular disorders. NPPB Protein, Human (His) is the recombinant human-derived NPPB protein, expressed by E. coli, with N-6*His labeled tag. The total length of NPPB Protein, Human (His) is 108 a.a., with molecular weight of ~15 kDa.
NPPB proteins are members of the natriuretic peptide family and are key regulators of cardiovascular homeostasis. As a hormone, NPPB is produced and released primarily by ventricular myocytes in response to increases in pressure and volume. NPPB Protein, Human (His, solution) is the recombinant human-derived NPPB protein, expressed by E. coli , with N-6*His labeled tag. The total length of NPPB Protein, Human (His, solution) is 108 a.a., with molecular weight of ~16.0 kDa.
NPPB proteins are members of the natriuretic peptide family and are key regulators of cardiovascular homeostasis. As a hormone, NPPB is produced and released primarily by ventricular myocytes in response to increases in pressure and volume. NPPB Protein, Human (76a.a, Flag-His) is the recombinant human-derived NPPB protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of NPPB Protein, Human (76a.a, Flag-His) is 76 a.a., with molecular weight of ~14.0 kDa.
Atrial natriuretic peptide receptor 2 (NPR2) serves as the receptor for C-type natriuretic peptide NPPC/CNP, activating guanylate cyclase upon ligand binding. NPR2 potentially regulates skeletal growth, indicating involvement in bone development. Its interaction with C-type natriuretic peptide highlights its significance in mediating cellular responses, especially in signaling pathways influencing skeletal growth dynamics. Atrial natriuretic peptide receptor 2/NPR2, Human (His) is the recombinant human-derived Atrial natriuretic peptide receptor 2/NPR2, expressed by P. pastoris , with N-His labeled tag. The total length of Atrial natriuretic peptide receptor 2/NPR2, Human (His) is 436 a.a., with molecular weight of ~51.0 kDa.
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .